Drug interactions
Marijuana + Oxazepam
Severity: Moderate
Marijuana and Oxazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabis causes drowsiness, slowed reaction time and impaired cognition, and combined with a benzodiazepine these effects are intensified. This raises the risk of accidents, falls and oversedation.
What this interaction means in plain words
Marijuana and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through cannabinoid receptor activity and GABA-A potentiation.
What to do
Counsel patients to avoid cannabis while taking oxazepam and not to drive or use machinery. Monitor for excessive sedation if use continues.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
Frequently asked questions
Can I take Marijuana with Oxazepam?
MediHelp rates the interaction as moderate. Marijuana and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabis causes drowsiness, slowed reaction time and impaired cognition, and combined with a benzodiazepine these effects are intensified. This raises the risk of accidents, falls and oversedation.
How serious is the interaction between Marijuana and Oxazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to avoid cannabis while taking oxazepam and not to drive or use machinery. Monitor for excessive sedation if use continues.
What other medicines interact with Oxazepam?
MediHelp also lists interactions of Oxazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Oxazepam page.
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