Drug interactions
Marijuana + Oxybutynin
Severity: Minor
Marijuana and Oxybutynin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabinoids can inhibit CYP3A4 in vitro, which might raise oxybutynin levels. Additive anticholinergic and CNS effects such as drowsiness, dizziness and tachycardia may also occur. Clinical significance is uncertain.
What this interaction means in plain words
Marijuana and Oxybutynin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible CYP3A4 inhibition by cannabinoids, plus additive CNS depressant effects.
What to do
Counsel patients about additive drowsiness and dizziness, and monitor for anticholinergic adverse effects such as dry mouth, confusion and tachycardia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxybutynin
Frequently asked questions
Can I take Marijuana with Oxybutynin?
MediHelp rates the interaction as minor. Marijuana and Oxybutynin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cannabinoids can inhibit CYP3A4 in vitro, which might raise oxybutynin levels. Additive anticholinergic and CNS effects such as drowsiness, dizziness and tachycardia may also occur. Clinical significance is uncertain.
How serious is the interaction between Marijuana and Oxybutynin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about additive drowsiness and dizziness, and monitor for anticholinergic adverse effects such as dry mouth, confusion and tachycardia.
What other medicines interact with Oxybutynin?
MediHelp also lists interactions of Oxybutynin with, for example, Bethanechol, Clozapine, Potassium chloride. The full list is on the Oxybutynin page.
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