Drug interactions
Marijuana + Pazopanib
Severity: Moderate
Marijuana and Pazopanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabinoids such as cannabidiol can inhibit CYP3A4 and may raise pazopanib concentrations. Evidence is limited and the effect likely depends on product and dose.
What this interaction means in plain words
Marijuana and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cannabinoid inhibition of CYP3A4 may reduce pazopanib clearance.
What to do
Ask patients about cannabis use and monitor liver enzymes and tolerability, reducing pazopanib if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Marijuana with Pazopanib?
MediHelp rates the interaction as moderate. Marijuana and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabinoids such as cannabidiol can inhibit CYP3A4 and may raise pazopanib concentrations. Evidence is limited and the effect likely depends on product and dose.
How serious is the interaction between Marijuana and Pazopanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ask patients about cannabis use and monitor liver enzymes and tolerability, reducing pazopanib if adverse effects occur.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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