Drug interactions
Marijuana + Sunitinib
Severity: Minor
Marijuana and Sunitinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabinoids such as cannabidiol can inhibit CYP3A4 in vitro, which could raise sunitinib levels. Clinical evidence is limited and the effect is likely variable.
What this interaction means in plain words
Marijuana and Sunitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible CYP3A4 inhibition by cannabinoids.
What to do
Ask patients about cannabis use and monitor for sunitinib adverse effects if use is regular.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Frequently asked questions
Can I take Marijuana with Sunitinib?
MediHelp rates the interaction as minor. Marijuana and Sunitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cannabinoids such as cannabidiol can inhibit CYP3A4 in vitro, which could raise sunitinib levels. Clinical evidence is limited and the effect is likely variable.
How serious is the interaction between Marijuana and Sunitinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ask patients about cannabis use and monitor for sunitinib adverse effects if use is regular.
What other medicines interact with Sunitinib?
MediHelp also lists interactions of Sunitinib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sunitinib page.
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