Drug interactions
Marijuana + Tadalafil
Severity: Minor
Marijuana and Tadalafil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabinoids may inhibit CYP3A4 in vitro, which could raise tadalafil levels slightly. Cannabis can also cause tachycardia and orthostatic hypotension, which may be additive with tadalafil.
What this interaction means in plain words
Marijuana and Tadalafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible CYP3A4 inhibition by cannabinoids plus additive cardiovascular effects.
What to do
Counsel patients about dizziness and hypotension, and monitor if symptoms occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Frequently asked questions
Can I take Marijuana with Tadalafil?
MediHelp rates the interaction as minor. Marijuana and Tadalafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cannabinoids may inhibit CYP3A4 in vitro, which could raise tadalafil levels slightly. Cannabis can also cause tachycardia and orthostatic hypotension, which may be additive with tadalafil.
How serious is the interaction between Marijuana and Tadalafil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about dizziness and hypotension, and monitor if symptoms occur.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
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