Drug interactions
Marijuana + Timolol
Severity: Minor
Marijuana and Timolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabinoids such as cannabidiol may inhibit CYP2D6, potentially raising timolol levels. Cannabis itself can cause tachycardia and blood pressure changes, so the net effect is unpredictable.
What this interaction means in plain words
Marijuana and Timolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible CYP2D6 inhibition by cannabinoids; clinical evidence is limited.
What to do
Monitor heart rate and blood pressure in regular cannabis users on timolol and ask the patient about cannabis use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Frequently asked questions
Can I take Marijuana with Timolol?
MediHelp rates the interaction as minor. Marijuana and Timolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cannabinoids such as cannabidiol may inhibit CYP2D6, potentially raising timolol levels. Cannabis itself can cause tachycardia and blood pressure changes, so the net effect is unpredictable.
How serious is the interaction between Marijuana and Timolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure in regular cannabis users on timolol and ask the patient about cannabis use.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Albuterol, Aldesleukin. The full list is on the Timolol page.
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