Drug interactions
Marijuana + Vinorelbine
Severity: Minor
Marijuana and Vinorelbine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabinoids can inhibit CYP3A4 in vitro, so vinorelbine levels might increase. The clinical relevance is unproven.
What this interaction means in plain words
Marijuana and Vinorelbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible CYP3A4 inhibition by cannabinoids.
What to do
No dose adjustment is needed. Monitor for enhanced vinorelbine toxicity such as neutropenia or constipation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vinorelbine
Frequently asked questions
Can I take Marijuana with Vinorelbine?
MediHelp rates the interaction as minor. Marijuana and Vinorelbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cannabinoids can inhibit CYP3A4 in vitro, so vinorelbine levels might increase. The clinical relevance is unproven.
How serious is the interaction between Marijuana and Vinorelbine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor for enhanced vinorelbine toxicity such as neutropenia or constipation.
What other medicines interact with Vinorelbine?
MediHelp also lists interactions of Vinorelbine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Belatacept. The full list is on the Vinorelbine page.
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