Drug interactions
Mavacamten + Olanzapine
Severity: Minor
Mavacamten and Olanzapine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mavacamten is metabolized mainly by CYP2C19, with a contribution from CYP3A4. Olanzapine is not an established CYP2C19 inhibitor, so any rise in mavacamten exposure is unlikely to be meaningful.
What this interaction means in plain words
Mavacamten and Olanzapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Mavacamten belongs to Cardiovascular; Olanzapine belongs to Central Nervous System.
Why it happens
A theoretical inhibitory effect on CYP2C19 that is not clinically established.
What to do
No empirical dose change is needed. Follow the standard mavacamten echocardiographic monitoring of LVEF.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Olanzapine
Other interactions of Mavacamten
- Apalutamide + Mavacamten Contraindicated
- Carbamazepine + Mavacamten Contraindicated
- Clarithromycin + Mavacamten Contraindicated
- Dexlansoprazole + Mavacamten Contraindicated
- Efavirenz + Mavacamten Contraindicated
- Enzalutamide + Mavacamten Contraindicated
Frequently asked questions
Can I take Mavacamten with Olanzapine?
MediHelp rates the interaction as minor. Mavacamten and Olanzapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mavacamten is metabolized mainly by CYP2C19, with a contribution from CYP3A4. Olanzapine is not an established CYP2C19 inhibitor, so any rise in mavacamten exposure is unlikely to be meaningful.
How serious is the interaction between Mavacamten and Olanzapine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed. Follow the standard mavacamten echocardiographic monitoring of LVEF.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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