Drug interactions
Mavacamten + Propranolol
Severity: Major
Mavacamten and Propranolol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mavacamten reduces cardiac contractility, and beta-blockers also have negative inotropic effects. Together they can worsen systolic function and cause heart failure, although beta-blockers are commonly used in obstructive hypertrophic cardiomyopathy. Propranolol may also affect mavacamten exposure through CYP inhibition.
What this interaction means in plain words
Mavacamten and Propranolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Mavacamten belongs to Cardiovascular; Propranolol belongs to Cardiovascular.
Why it happens
Additive negative inotropic effects.
What to do
Monitor left ventricular ejection fraction and clinical signs of heart failure per mavacamten labeling. Interrupt mavacamten if systolic function falls.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Albuterol + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
Other interactions of Mavacamten
- Apalutamide + Mavacamten Contraindicated
- Carbamazepine + Mavacamten Contraindicated
- Clarithromycin + Mavacamten Contraindicated
- Dexlansoprazole + Mavacamten Contraindicated
- Efavirenz + Mavacamten Contraindicated
- Enzalutamide + Mavacamten Contraindicated
Frequently asked questions
Can I take Mavacamten with Propranolol?
MediHelp rates the interaction as major. Mavacamten and Propranolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mavacamten reduces cardiac contractility, and beta-blockers also have negative inotropic effects. Together they can worsen systolic function and cause heart failure, although beta-blockers are commonly used in obstructive hypertrophic cardiomyopathy. Propranolol may also affect mavacamten exposure through CYP inhibition.
How serious is the interaction between Mavacamten and Propranolol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor left ventricular ejection fraction and clinical signs of heart failure per mavacamten labeling. Interrupt mavacamten if systolic function falls.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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