Drug interactions
Mavacamten + Rabeprazole
Severity: Major
Mavacamten and Rabeprazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rabeprazole may raise mavacamten exposure through CYP2C19 inhibition, though its effect is weaker than other PPIs. Excess mavacamten can reduce ejection fraction and cause systolic heart failure.
What this interaction means in plain words
Mavacamten and Rabeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Mavacamten belongs to Cardiovascular; Rabeprazole belongs to Gastrointestinal Tract.
Why it happens
Inhibition of CYP2C19-mediated metabolism of mavacamten may increase its plasma concentrations.
What to do
Prefer an acid suppressant without CYP2C19 inhibition, such as an H2 blocker. If used together, monitor left ventricular ejection fraction by echocardiography and follow label dose guidance.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Other interactions of Mavacamten
- Apalutamide + Mavacamten Contraindicated
- Carbamazepine + Mavacamten Contraindicated
- Clarithromycin + Mavacamten Contraindicated
- Dexlansoprazole + Mavacamten Contraindicated
- Efavirenz + Mavacamten Contraindicated
- Enzalutamide + Mavacamten Contraindicated
Frequently asked questions
Can I take Mavacamten with Rabeprazole?
MediHelp rates the interaction as major. Mavacamten and Rabeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rabeprazole may raise mavacamten exposure through CYP2C19 inhibition, though its effect is weaker than other PPIs. Excess mavacamten can reduce ejection fraction and cause systolic heart failure.
How serious is the interaction between Mavacamten and Rabeprazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an acid suppressant without CYP2C19 inhibition, such as an H2 blocker. If used together, monitor left ventricular ejection fraction by echocardiography and follow label dose guidance.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
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