Drug interactions
Mavacamten + Sildenafil
Severity: Minor
Mavacamten and Sildenafil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mavacamten is metabolized mainly by CYP2C19 and CYP3A4, and sildenafil is not a recognized meaningful CYP2C19 inhibitor. A clinically significant pharmacokinetic interaction is not established, although both drugs can lower blood pressure.
What this interaction means in plain words
Mavacamten and Sildenafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Mavacamten belongs to Cardiovascular; Sildenafil belongs to Genitourinary.
Why it happens
No established mechanism; possible additive vasodilatory effects.
What to do
Monitor blood pressure and symptoms of outflow obstruction when starting sildenafil in patients on mavacamten.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sildenafil
- Amyl nitrite + Sildenafil Contraindicated
- Atazanavir + Sildenafil Contraindicated
- Cobicistat + Sildenafil Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Sildenafil Contraindicated
- Glyceryl trinitrate pr + Sildenafil Contraindicated
- Isosorbide dinitrate + Sildenafil Contraindicated
Other interactions of Mavacamten
- Apalutamide + Mavacamten Contraindicated
- Carbamazepine + Mavacamten Contraindicated
- Clarithromycin + Mavacamten Contraindicated
- Dexlansoprazole + Mavacamten Contraindicated
- Efavirenz + Mavacamten Contraindicated
- Enzalutamide + Mavacamten Contraindicated
Frequently asked questions
Can I take Mavacamten with Sildenafil?
MediHelp rates the interaction as minor. Mavacamten and Sildenafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mavacamten is metabolized mainly by CYP2C19 and CYP3A4, and sildenafil is not a recognized meaningful CYP2C19 inhibitor. A clinically significant pharmacokinetic interaction is not established, although both drugs can lower blood pressure.
How serious is the interaction between Mavacamten and Sildenafil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and symptoms of outflow obstruction when starting sildenafil in patients on mavacamten.
What other medicines interact with Sildenafil?
MediHelp also lists interactions of Sildenafil with, for example, Amyl nitrite, Atazanavir, Cobicistat. The full list is on the Sildenafil page.
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