Drug interactions
Mavacamten + Topiramate
Severity: Moderate
Mavacamten and Topiramate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Topiramate is a weak CYP2C19 inhibitor and may raise mavacamten exposure. Higher mavacamten levels can reduce left ventricular ejection fraction and increase the risk of heart failure.
What this interaction means in plain words
Mavacamten and Topiramate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mavacamten belongs to Cardiovascular; Topiramate belongs to Central Nervous System.
Why it happens
Inhibition of CYP2C19-mediated metabolism of mavacamten by topiramate.
What to do
Monitor left ventricular ejection fraction closely when topiramate is started or stopped, and follow labeled echocardiographic monitoring. Adjust the mavacamten dose according to LVEF and clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Topiramate
Other interactions of Mavacamten
- Apalutamide + Mavacamten Contraindicated
- Carbamazepine + Mavacamten Contraindicated
- Clarithromycin + Mavacamten Contraindicated
- Dexlansoprazole + Mavacamten Contraindicated
- Efavirenz + Mavacamten Contraindicated
- Enzalutamide + Mavacamten Contraindicated
Frequently asked questions
Can I take Mavacamten with Topiramate?
MediHelp rates the interaction as moderate. Mavacamten and Topiramate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Topiramate is a weak CYP2C19 inhibitor and may raise mavacamten exposure. Higher mavacamten levels can reduce left ventricular ejection fraction and increase the risk of heart failure.
How serious is the interaction between Mavacamten and Topiramate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor left ventricular ejection fraction closely when topiramate is started or stopped, and follow labeled echocardiographic monitoring. Adjust the mavacamten dose according to LVEF and clinical response.
What other medicines interact with Topiramate?
MediHelp also lists interactions of Topiramate with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Topiramate page.
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