Drug interactions
Measles mumps and rubella vaccine + Muromonab cd3
Severity: Contraindicated
Measles mumps and rubella vaccine and Muromonab cd3: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Muromonab-CD3 causes profound T-cell depletion, so the live attenuated vaccine viruses may replicate unchecked and cause disseminated vaccine-strain disease. The vaccine response is also likely to be inadequate.
What this interaction means in plain words
Measles mumps and rubella vaccine and Muromonab cd3 are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Profound T-cell depletion and immunosuppression permit uncontrolled replication of live attenuated viruses and blunt vaccine immunogenicity.
What to do
Do not give live MMR vaccine during or shortly after muromonab-CD3 therapy; defer until immune recovery is confirmed and use inactivated vaccines where appropriate.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Measles mumps and rubella vaccine
- Adalimumab + Measles mumps and rubella vaccine Contraindicated
- Anakinra + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin equine + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin rabbit + Measles mumps and rubella vaccine Contraindicated
- Azathioprine + Measles mumps and rubella vaccine Contraindicated
- Basiliximab + Measles mumps and rubella vaccine Contraindicated
Frequently asked questions
Can I take Measles mumps and rubella vaccine with Muromonab cd3?
MediHelp rates the interaction as contraindicated. Measles mumps and rubella vaccine and Muromonab cd3 are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Muromonab-CD3 causes profound T-cell depletion, so the live attenuated vaccine viruses may replicate unchecked and cause disseminated vaccine-strain disease. The vaccine response is also likely to be inadequate.
How serious is the interaction between Measles mumps and rubella vaccine and Muromonab cd3?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give live MMR vaccine during or shortly after muromonab-CD3 therapy; defer until immune recovery is confirmed and use inactivated vaccines where appropriate.
What other medicines interact with Measles mumps and rubella vaccine?
MediHelp also lists interactions of Measles mumps and rubella vaccine with, for example, Adalimumab, Anakinra, Antithymocyte globulin equine. The full list is on the Measles mumps and rubella vaccine page.
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