Drug interactions
Measles mumps and rubella vaccine + Mycophenolate
Severity: Contraindicated
Measles mumps and rubella vaccine and Mycophenolate: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mycophenolate suppresses lymphocyte proliferation, which can allow the live attenuated vaccine viruses to cause disease and reduces the protective antibody response. Live vaccines are generally avoided in patients taking it.
What this interaction means in plain words
Measles mumps and rubella vaccine and Mycophenolate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Inhibition of inosine monophosphate dehydrogenase depletes proliferating T and B lymphocytes, impairing control of live vaccine viruses.
What to do
Avoid live MMR vaccine during mycophenolate treatment; give it, if needed, well before starting therapy or after immunosuppression is discontinued and immune recovery is documented.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Measles mumps and rubella vaccine
- Adalimumab + Measles mumps and rubella vaccine Contraindicated
- Anakinra + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin equine + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin rabbit + Measles mumps and rubella vaccine Contraindicated
- Azathioprine + Measles mumps and rubella vaccine Contraindicated
- Basiliximab + Measles mumps and rubella vaccine Contraindicated
Frequently asked questions
Can I take Measles mumps and rubella vaccine with Mycophenolate?
MediHelp rates the interaction as contraindicated. Measles mumps and rubella vaccine and Mycophenolate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Mycophenolate suppresses lymphocyte proliferation, which can allow the live attenuated vaccine viruses to cause disease and reduces the protective antibody response. Live vaccines are generally avoided in patients taking it.
How serious is the interaction between Measles mumps and rubella vaccine and Mycophenolate?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live MMR vaccine during mycophenolate treatment; give it, if needed, well before starting therapy or after immunosuppression is discontinued and immune recovery is documented.
What other medicines interact with Measles mumps and rubella vaccine?
MediHelp also lists interactions of Measles mumps and rubella vaccine with, for example, Adalimumab, Anakinra, Antithymocyte globulin equine. The full list is on the Measles mumps and rubella vaccine page.
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