Drug interactions
Measles mumps and rubella vaccine + Ofatumumab sc
Severity: Major
Measles mumps and rubella vaccine and Ofatumumab sc: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ofatumumab depletes B cells, which may blunt vaccine responses and raises concern for vaccine-strain infection with live vaccines. Labeling advises avoiding live vaccines during treatment and until B-cell recovery.
What this interaction means in plain words
Measles mumps and rubella vaccine and Ofatumumab sc can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Anti-CD20 B-cell depletion causes immunosuppression and impaired humoral response to vaccines.
What to do
Give MMR at least 4 weeks before starting ofatumumab; avoid live vaccines during treatment and until B-cell repletion.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Measles mumps and rubella vaccine
- Adalimumab + Measles mumps and rubella vaccine Contraindicated
- Anakinra + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin equine + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin rabbit + Measles mumps and rubella vaccine Contraindicated
- Azathioprine + Measles mumps and rubella vaccine Contraindicated
- Basiliximab + Measles mumps and rubella vaccine Contraindicated
Frequently asked questions
Can I take Measles mumps and rubella vaccine with Ofatumumab sc?
MediHelp rates the interaction as major. Measles mumps and rubella vaccine and Ofatumumab sc can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ofatumumab depletes B cells, which may blunt vaccine responses and raises concern for vaccine-strain infection with live vaccines. Labeling advises avoiding live vaccines during treatment and until B-cell recovery.
How serious is the interaction between Measles mumps and rubella vaccine and Ofatumumab sc?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give MMR at least 4 weeks before starting ofatumumab; avoid live vaccines during treatment and until B-cell repletion.
What other medicines interact with Measles mumps and rubella vaccine?
MediHelp also lists interactions of Measles mumps and rubella vaccine with, for example, Adalimumab, Anakinra, Antithymocyte globulin equine. The full list is on the Measles mumps and rubella vaccine page.
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