Drug interactions
Measles mumps and rubella vaccine + Rabies immune globulin human
Severity: Moderate
Measles mumps and rubella vaccine and Rabies immune globulin human: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rabies immune globulin contains antibodies that may reduce the replication of live MMR vaccine viruses. This can lower the immune response to the vaccine.
What this interaction means in plain words
Measles mumps and rubella vaccine and Rabies immune globulin human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Passive antibodies partially neutralize live attenuated vaccine viruses, impairing immunogenicity.
What to do
Defer MMR vaccination for the interval recommended in immunization guidelines after rabies immune globulin, commonly around 3 months. Rabies post-exposure treatment should not be delayed for this reason.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Measles mumps and rubella vaccine
- Adalimumab + Measles mumps and rubella vaccine Contraindicated
- Anakinra + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin equine + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin rabbit + Measles mumps and rubella vaccine Contraindicated
- Azathioprine + Measles mumps and rubella vaccine Contraindicated
- Basiliximab + Measles mumps and rubella vaccine Contraindicated
Frequently asked questions
Can I take Measles mumps and rubella vaccine with Rabies immune globulin human?
MediHelp rates the interaction as moderate. Measles mumps and rubella vaccine and Rabies immune globulin human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rabies immune globulin contains antibodies that may reduce the replication of live MMR vaccine viruses. This can lower the immune response to the vaccine.
How serious is the interaction between Measles mumps and rubella vaccine and Rabies immune globulin human?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Defer MMR vaccination for the interval recommended in immunization guidelines after rabies immune globulin, commonly around 3 months. Rabies post-exposure treatment should not be delayed for this reason.
What other medicines interact with Measles mumps and rubella vaccine?
MediHelp also lists interactions of Measles mumps and rubella vaccine with, for example, Adalimumab, Anakinra, Antithymocyte globulin equine. The full list is on the Measles mumps and rubella vaccine page.
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