Drug interactions
Measles mumps and rubella vaccine + Rho immune globulin
Severity: Moderate
Measles mumps and rubella vaccine and Rho immune globulin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antibodies in Rho(D) immune globulin may interfere with the replication of live measles, mumps and rubella vaccine viruses and reduce seroconversion. Protection, particularly against rubella and measles, may be inadequate.
What this interaction means in plain words
Measles mumps and rubella vaccine and Rho immune globulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Passive antibodies neutralize live vaccine viruses, blunting the active immune response.
What to do
Postpartum MMR may still be given when rubella-nonimmune but check rubella serology about 3 months later and revaccinate if needed; otherwise defer MMR for about 3 months after Rho(D) immune globulin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Measles mumps and rubella vaccine
- Adalimumab + Measles mumps and rubella vaccine Contraindicated
- Anakinra + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin equine + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin rabbit + Measles mumps and rubella vaccine Contraindicated
- Azathioprine + Measles mumps and rubella vaccine Contraindicated
- Basiliximab + Measles mumps and rubella vaccine Contraindicated
Frequently asked questions
Can I take Measles mumps and rubella vaccine with Rho immune globulin?
MediHelp rates the interaction as moderate. Measles mumps and rubella vaccine and Rho immune globulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antibodies in Rho(D) immune globulin may interfere with the replication of live measles, mumps and rubella vaccine viruses and reduce seroconversion. Protection, particularly against rubella and measles, may be inadequate.
How serious is the interaction between Measles mumps and rubella vaccine and Rho immune globulin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Postpartum MMR may still be given when rubella-nonimmune but check rubella serology about 3 months later and revaccinate if needed; otherwise defer MMR for about 3 months after Rho(D) immune globulin.
What other medicines interact with Measles mumps and rubella vaccine?
MediHelp also lists interactions of Measles mumps and rubella vaccine with, for example, Adalimumab, Anakinra, Antithymocyte globulin equine. The full list is on the Measles mumps and rubella vaccine page.
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