Drug interactions
Measles mumps and rubella vaccine + Vaccinia immune globulin intravenous
Severity: Moderate
Measles mumps and rubella vaccine and Vaccinia immune globulin intravenous: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vaccinia immune globulin given intravenously delivers large amounts of antibody that can neutralize live vaccine viruses. The MMR vaccine may therefore be less effective if given soon afterwards.
What this interaction means in plain words
Measles mumps and rubella vaccine and Vaccinia immune globulin intravenous can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Passively transferred antibodies neutralize live attenuated measles, mumps and rubella viruses.
What to do
Postpone MMR vaccination for the interval in current guidelines after IV immune globulin products, which is at least several months. Reassess immunity by serology or revaccinate if the vaccine was given too early.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Measles mumps and rubella vaccine
- Adalimumab + Measles mumps and rubella vaccine Contraindicated
- Anakinra + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin equine + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin rabbit + Measles mumps and rubella vaccine Contraindicated
- Azathioprine + Measles mumps and rubella vaccine Contraindicated
- Basiliximab + Measles mumps and rubella vaccine Contraindicated
Frequently asked questions
Can I take Measles mumps and rubella vaccine with Vaccinia immune globulin intravenous?
MediHelp rates the interaction as moderate. Measles mumps and rubella vaccine and Vaccinia immune globulin intravenous can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vaccinia immune globulin given intravenously delivers large amounts of antibody that can neutralize live vaccine viruses. The MMR vaccine may therefore be less effective if given soon afterwards.
How serious is the interaction between Measles mumps and rubella vaccine and Vaccinia immune globulin intravenous?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Postpone MMR vaccination for the interval in current guidelines after IV immune globulin products, which is at least several months. Reassess immunity by serology or revaccinate if the vaccine was given too early.
What other medicines interact with Measles mumps and rubella vaccine?
MediHelp also lists interactions of Measles mumps and rubella vaccine with, for example, Adalimumab, Anakinra, Antithymocyte globulin equine. The full list is on the Measles mumps and rubella vaccine page.
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