Drug interactions
Measles mumps and rubella vaccine live + Triamcinolone
Severity: Major
Measles mumps and rubella vaccine live and Triamcinolone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This live attenuated vaccine can cause disseminated vaccine-virus infection in patients receiving immunosuppressive corticosteroids, and the vaccine response may also be reduced.
What this interaction means in plain words
Measles mumps and rubella vaccine live and Triamcinolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Corticosteroid immunosuppression impairs control of replicating attenuated viruses and reduces vaccine immunogenicity.
What to do
Avoid giving it during immunosuppressive corticosteroid therapy and defer until treatment has been stopped for the interval recommended in guidelines (commonly at least one month). Low-dose, short-course or local-only use is usually not a barrier.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Triamcinolone
- Smallpox vaccine live + Triamcinolone Contraindicated
- Triamcinolone + Zoster vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Triamcinolone Major
- Aldesleukin + Triamcinolone Major
- Atazanavir + Triamcinolone Major
- Axicabtagene ciloleucel + Triamcinolone Major
Frequently asked questions
Can I take Measles mumps and rubella vaccine live with Triamcinolone?
MediHelp rates the interaction as major. Measles mumps and rubella vaccine live and Triamcinolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. This live attenuated vaccine can cause disseminated vaccine-virus infection in patients receiving immunosuppressive corticosteroids, and the vaccine response may also be reduced.
How serious is the interaction between Measles mumps and rubella vaccine live and Triamcinolone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving it during immunosuppressive corticosteroid therapy and defer until treatment has been stopped for the interval recommended in guidelines (commonly at least one month). Low-dose, short-course or local-only use is usually not a barrier.
What other medicines interact with Triamcinolone?
MediHelp also lists interactions of Triamcinolone with, for example, Smallpox vaccine live, Zoster vaccine live, Adenovirus types 4 and 7 live. The full list is on the Triamcinolone page.
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