Drug interactions
Tocilizumab + Typhoid vaccine live
Severity: Contraindicated
Tocilizumab and Typhoid vaccine live: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral live attenuated typhoid vaccine (Ty21a) may cause systemic Salmonella infection in immunosuppressed patients. Tocilizumab also impairs the vaccine response.
What this interaction means in plain words
Tocilizumab and Typhoid vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Immunosuppression from IL-6 receptor blockade impairs control of live attenuated bacteria.
What to do
Avoid the live typhoid vaccine in patients on tocilizumab and use the inactivated polysaccharide vaccine instead.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Tocilizumab
- Bcg vaccine live + Tocilizumab Contraindicated
- Measles mumps and rubella vaccine live + Tocilizumab Contraindicated
- Measles mumps rubella and varicella vaccine live + Tocilizumab Contraindicated
- Measles vaccine + Tocilizumab Contraindicated
- Rubella vaccine + Tocilizumab Contraindicated
- Smallpox vaccine live + Tocilizumab Contraindicated
Frequently asked questions
Can I take Tocilizumab with Typhoid vaccine live?
MediHelp rates the interaction as contraindicated. Tocilizumab and Typhoid vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Oral live attenuated typhoid vaccine (Ty21a) may cause systemic Salmonella infection in immunosuppressed patients. Tocilizumab also impairs the vaccine response.
How serious is the interaction between Tocilizumab and Typhoid vaccine live?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the live typhoid vaccine in patients on tocilizumab and use the inactivated polysaccharide vaccine instead.
What other medicines interact with Tocilizumab?
MediHelp also lists interactions of Tocilizumab with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Tocilizumab page.
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