Drug interactions
Mecasermin + Metformin
Severity: Moderate
Mecasermin and Metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mecasermin lowers blood glucose with insulin-like effects. Metformin rarely causes hypoglycemia alone, but the combination may still increase the risk of low glucose.
What this interaction means in plain words
Mecasermin and Metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mecasermin belongs to Endocrine; Metformin belongs to Endocrine.
Why it happens
Additive glucose lowering from IGF-1 receptor activation and reduced hepatic glucose output.
What to do
Monitor blood glucose and adjust the metformin dose if hypoglycemia occurs. Give mecasermin with food.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mecasermin
Other interactions of Metformin
Frequently asked questions
Can I take Mecasermin with Metformin?
MediHelp rates the interaction as moderate. Mecasermin and Metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mecasermin lowers blood glucose with insulin-like effects. Metformin rarely causes hypoglycemia alone, but the combination may still increase the risk of low glucose.
How serious is the interaction between Mecasermin and Metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and adjust the metformin dose if hypoglycemia occurs. Give mecasermin with food.
What other medicines interact with Mecasermin?
MediHelp also lists interactions of Mecasermin with, for example, Gliclazide, Glyburide-metformin, Insulin degludec-insulin aspart. The full list is on the Mecasermin page.
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