Drug interactions
Meclizine + Scopolamine
Severity: Moderate
Meclizine and Scopolamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meclizine is an antihistamine with anticholinergic and sedative properties, and scopolamine has similar effects. Together they may cause pronounced drowsiness, dry mouth, blurred vision, confusion and urinary retention.
What this interaction means in plain words
Meclizine and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Meclizine belongs to Respiratory; Scopolamine belongs to Respiratory.
Why it happens
Additive muscarinic receptor antagonism and central sedation.
What to do
Avoid using both for motion sickness or vertigo when possible, and monitor for sedation and anticholinergic effects, particularly in older adults.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Scopolamine
Other interactions of Meclizine
Frequently asked questions
Can I take Meclizine with Scopolamine?
MediHelp rates the interaction as moderate. Meclizine and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meclizine is an antihistamine with anticholinergic and sedative properties, and scopolamine has similar effects. Together they may cause pronounced drowsiness, dry mouth, blurred vision, confusion and urinary retention.
How serious is the interaction between Meclizine and Scopolamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using both for motion sickness or vertigo when possible, and monitor for sedation and anticholinergic effects, particularly in older adults.
What other medicines interact with Scopolamine?
MediHelp also lists interactions of Scopolamine with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Scopolamine page.
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