Drug interactions
Meclizine + Streptomycin
Severity: Moderate
Meclizine and Streptomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meclizine suppresses vestibular symptoms such as vertigo and nausea, which can mask early signs of aminoglycoside vestibular toxicity. Delayed recognition could allow irreversible ototoxicity to progress.
What this interaction means in plain words
Meclizine and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Meclizine belongs to Respiratory; Streptomycin belongs to Anti Bacterial.
Why it happens
Pharmacodynamic masking of ototoxicity symptoms by vestibular suppression, with no pharmacokinetic interaction.
What to do
Monitor vestibular and auditory function with objective testing rather than relying on symptoms. Reassess the need for meclizine if dizziness arises during streptomycin therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Streptomycin
Other interactions of Meclizine
Frequently asked questions
Can I take Meclizine with Streptomycin?
MediHelp rates the interaction as moderate. Meclizine and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meclizine suppresses vestibular symptoms such as vertigo and nausea, which can mask early signs of aminoglycoside vestibular toxicity. Delayed recognition could allow irreversible ototoxicity to progress.
How serious is the interaction between Meclizine and Streptomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor vestibular and auditory function with objective testing rather than relying on symptoms. Reassess the need for meclizine if dizziness arises during streptomycin therapy.
What other medicines interact with Streptomycin?
MediHelp also lists interactions of Streptomycin with, for example, Abobotulinumtoxina, Adefovir, Amikacin. The full list is on the Streptomycin page.
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