Drug interactions
Meclizine + Tolterodine
Severity: Moderate
Meclizine and Tolterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meclizine is an antihistamine with antimuscarinic activity, so it adds to tolterodine's anticholinergic effects. Patients may have dry mouth, constipation, urinary retention, drowsiness and confusion.
What this interaction means in plain words
Meclizine and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Meclizine belongs to Respiratory; Tolterodine belongs to Genitourinary.
Why it happens
Additive antimuscarinic effects.
What to do
Monitor for urinary retention and cognitive effects, especially in older adults. Limit meclizine use or choose an alternative if anticholinergic effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolterodine
Other interactions of Meclizine
Frequently asked questions
Can I take Meclizine with Tolterodine?
MediHelp rates the interaction as moderate. Meclizine and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meclizine is an antihistamine with antimuscarinic activity, so it adds to tolterodine's anticholinergic effects. Patients may have dry mouth, constipation, urinary retention, drowsiness and confusion.
How serious is the interaction between Meclizine and Tolterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for urinary retention and cognitive effects, especially in older adults. Limit meclizine use or choose an alternative if anticholinergic effects appear.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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