Drug interactions
Meclofenamate + Moexipril
Severity: Moderate
Meclofenamate and Moexipril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meclofenamate can reduce the blood pressure lowering effect of moexipril and increase the risk of renal function decline and hyperkalemia. The risk is greatest in elderly, volume-depleted or renally impaired patients and with diuretics.
What this interaction means in plain words
Meclofenamate and Moexipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces renal blood flow and sodium excretion, opposing ACE inhibitor effects.
What to do
Monitor blood pressure, serum creatinine and potassium within the first weeks and maintain hydration. Use the lowest effective NSAID dose for the shortest time or choose paracetamol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moexipril
- Aliskiren + Moexipril Contraindicated
- Moexipril + Protein a column Contraindicated
- Moexipril + Sacubitril / valsartan Contraindicated
- Moexipril + Sacubitril-valsartan Contraindicated
- Amifostine + Moexipril Major
- Amiloride + Moexipril Major
Frequently asked questions
Can I take Meclofenamate with Moexipril?
MediHelp rates the interaction as moderate. Meclofenamate and Moexipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meclofenamate can reduce the blood pressure lowering effect of moexipril and increase the risk of renal function decline and hyperkalemia. The risk is greatest in elderly, volume-depleted or renally impaired patients and with diuretics.
How serious is the interaction between Meclofenamate and Moexipril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium within the first weeks and maintain hydration. Use the lowest effective NSAID dose for the shortest time or choose paracetamol.
What other medicines interact with Moexipril?
MediHelp also lists interactions of Moexipril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Moexipril page.
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