Drug interactions
Meclofenamate + Naproxen
Severity: Moderate
Meclofenamate and Naproxen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two systemic NSAIDs adds no proven therapeutic benefit and increases the risk of gastrointestinal ulceration and bleeding, renal impairment and fluid retention. Platelet inhibition and the potential for hyperkalemia are additive.
What this interaction means in plain words
Meclofenamate and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Both drugs inhibit cyclooxygenase, producing additive effects on platelet function, gastric mucosal protection and renal prostaglandin-dependent perfusion.
What to do
Avoid concurrent use of two NSAIDs and use a single agent at the lowest effective dose. If overlap is unavoidable, monitor for GI bleeding and check renal function and potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Frequently asked questions
Can I take Meclofenamate with Naproxen?
MediHelp rates the interaction as moderate. Meclofenamate and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining two systemic NSAIDs adds no proven therapeutic benefit and increases the risk of gastrointestinal ulceration and bleeding, renal impairment and fluid retention. Platelet inhibition and the potential for hyperkalemia are additive.
How serious is the interaction between Meclofenamate and Naproxen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two NSAIDs and use a single agent at the lowest effective dose. If overlap is unavoidable, monitor for GI bleeding and check renal function and potassium.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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