Drug interactions
Meclofenamate + Ofloxacin
Severity: Moderate
Meclofenamate and Ofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may increase the CNS stimulating and seizure-provoking potential of fluoroquinolones. The effect is uncommon but is more relevant in patients with seizure risk factors or renal impairment.
What this interaction means in plain words
Meclofenamate and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Fluoroquinolone inhibition of GABA-A receptor binding, possibly enhanced by NSAIDs.
What to do
Avoid in patients with epilepsy or prior seizures. Otherwise monitor for CNS excitation and stop ofloxacin if it occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Frequently asked questions
Can I take Meclofenamate with Ofloxacin?
MediHelp rates the interaction as moderate. Meclofenamate and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may increase the CNS stimulating and seizure-provoking potential of fluoroquinolones. The effect is uncommon but is more relevant in patients with seizure risk factors or renal impairment.
How serious is the interaction between Meclofenamate and Ofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in patients with epilepsy or prior seizures. Otherwise monitor for CNS excitation and stop ofloxacin if it occurs.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
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