Drug interactions
Meclofenamate + Sacubitril-valsartan
Severity: Moderate
Meclofenamate and Sacubitril-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as meclofenamate can blunt the blood pressure lowering effect of sacubitril-valsartan and reduce renal function, especially in older, volume-depleted or renally impaired patients. The combination also raises the risk of hyperkalemia and acute kidney injury.
What this interaction means in plain words
Meclofenamate and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces renal blood flow and sodium excretion, which opposes the vasodilatory effect and worsens angiotensin receptor blockade-related renal hemodynamic effects.
What to do
Avoid regular NSAID use where possible and prefer paracetamol for analgesia. If the combination is necessary, monitor blood pressure, serum creatinine and potassium, and ensure adequate hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Frequently asked questions
Can I take Meclofenamate with Sacubitril-valsartan?
MediHelp rates the interaction as moderate. Meclofenamate and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as meclofenamate can blunt the blood pressure lowering effect of sacubitril-valsartan and reduce renal function, especially in older, volume-depleted or renally impaired patients. The combination also raises the risk of hyperkalemia and acute kidney injury.
How serious is the interaction between Meclofenamate and Sacubitril-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use where possible and prefer paracetamol for analgesia. If the combination is necessary, monitor blood pressure, serum creatinine and potassium, and ensure adequate hydration.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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