Drug interactions
Meclofenamate + Terazosin
Severity: Moderate
Meclofenamate and Terazosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meclofenamate, an NSAID, may reduce the blood pressure lowering effect of terazosin. The effect is more likely with regular use and in patients with existing hypertension or renal impairment.
What this interaction means in plain words
Meclofenamate and Terazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of prostaglandin synthesis causes sodium and fluid retention and opposes vasodilation.
What to do
Monitor blood pressure when starting or stopping the NSAID, and use the lowest effective dose for the shortest duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Terazosin
- Alfuzosin + Terazosin Major
- Amifostine + Terazosin Major
- Avanafil + Terazosin Major
- Doxazosin + Terazosin Major
- Dutasteride-tamsulosin + Terazosin Major
- Lofexidine + Terazosin Major
Frequently asked questions
Can I take Meclofenamate with Terazosin?
MediHelp rates the interaction as moderate. Meclofenamate and Terazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meclofenamate, an NSAID, may reduce the blood pressure lowering effect of terazosin. The effect is more likely with regular use and in patients with existing hypertension or renal impairment.
How serious is the interaction between Meclofenamate and Terazosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when starting or stopping the NSAID, and use the lowest effective dose for the shortest duration.
What other medicines interact with Terazosin?
MediHelp also lists interactions of Terazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Terazosin page.
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