Drug interactions
Meclofenamate + Timolol
Severity: Moderate
Meclofenamate and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meclofenamate and other NSAIDs can reduce the antihypertensive effect of beta-blockers with continued use. They may also impair renal function and slightly raise potassium.
What this interaction means in plain words
Meclofenamate and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of prostaglandin synthesis causing sodium and fluid retention that opposes beta-blocker effect.
What to do
Monitor blood pressure when meclofenamate is used for more than about a week, and check renal function and potassium in at-risk patients. Use the lowest effective NSAID dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Frequently asked questions
Can I take Meclofenamate with Timolol?
MediHelp rates the interaction as moderate. Meclofenamate and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meclofenamate and other NSAIDs can reduce the antihypertensive effect of beta-blockers with continued use. They may also impair renal function and slightly raise potassium.
How serious is the interaction between Meclofenamate and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when meclofenamate is used for more than about a week, and check renal function and potassium in at-risk patients. Use the lowest effective NSAID dose.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Albuterol, Aldesleukin. The full list is on the Timolol page.
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