Drug interactions
Meclofenamate + Tolmetin
Severity: Major
Meclofenamate and Tolmetin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are NSAIDs, so combining them duplicates therapy without added benefit. It increases the risk of gastrointestinal bleeding, ulceration, renal injury and hyperkalemia.
What this interaction means in plain words
Meclofenamate and Tolmetin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Duplicate COX inhibition giving additive gastrointestinal, platelet, and renal prostaglandin effects.
What to do
Avoid using two NSAIDs together; choose a single agent at the lowest effective dose. Monitor renal function and potassium if combined inadvertently.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Frequently asked questions
Can I take Meclofenamate with Tolmetin?
MediHelp rates the interaction as major. Meclofenamate and Tolmetin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are NSAIDs, so combining them duplicates therapy without added benefit. It increases the risk of gastrointestinal bleeding, ulceration, renal injury and hyperkalemia.
How serious is the interaction between Meclofenamate and Tolmetin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two NSAIDs together; choose a single agent at the lowest effective dose. Monitor renal function and potassium if combined inadvertently.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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