Drug interactions
Meclofenamate + Valsartan
Severity: Moderate
Meclofenamate and Valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meclofenamate, an NSAID, can reduce the blood pressure lowering effect of valsartan and increase the risk of acute kidney injury and hyperkalemia. The risk is greatest in older patients, those who are volume depleted, and those with pre-existing renal disease.
What this interaction means in plain words
Meclofenamate and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces renal perfusion and sodium excretion, compounding ARB effects on glomerular filtration and potassium handling.
What to do
Monitor blood pressure, creatinine and potassium, and maintain hydration. Use the lowest effective NSAID dose for the shortest time or choose an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Frequently asked questions
Can I take Meclofenamate with Valsartan?
MediHelp rates the interaction as moderate. Meclofenamate and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meclofenamate, an NSAID, can reduce the blood pressure lowering effect of valsartan and increase the risk of acute kidney injury and hyperkalemia. The risk is greatest in older patients, those who are volume depleted, and those with pre-existing renal disease.
How serious is the interaction between Meclofenamate and Valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, creatinine and potassium, and maintain hydration. Use the lowest effective NSAID dose for the shortest time or choose an alternative analgesic.
What other medicines interact with Valsartan?
MediHelp also lists interactions of Valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Valsartan page.
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