Drug interactions
Meclofenamic acid + Methotrexate
Severity: Major
Meclofenamic acid and Methotrexate: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can raise and prolong methotrexate concentrations, which has led to severe myelosuppression, mucositis and renal toxicity, particularly with high-dose methotrexate. The risk is much lower with low-dose weekly regimens but still present in renal impairment.
What this interaction means in plain words
Meclofenamic acid and Methotrexate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Meclofenamic acid belongs to Musculoskeletal; Methotrexate belongs to Oncology.
Why it happens
Reduced renal blood flow and competition for tubular secretion decrease methotrexate clearance.
What to do
Avoid NSAIDs with high-dose methotrexate. With low-dose methotrexate, monitor blood counts, creatinine and signs of toxicity, and avoid use in renal impairment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Frequently asked questions
Can I take Meclofenamic acid with Methotrexate?
MediHelp rates the interaction as major. Meclofenamic acid and Methotrexate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs can raise and prolong methotrexate concentrations, which has led to severe myelosuppression, mucositis and renal toxicity, particularly with high-dose methotrexate. The risk is much lower with low-dose weekly regimens but still present in renal impairment.
How serious is the interaction between Meclofenamic acid and Methotrexate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid NSAIDs with high-dose methotrexate. With low-dose methotrexate, monitor blood counts, creatinine and signs of toxicity, and avoid use in renal impairment.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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