Drug interactions
Meclofenamic acid + Mipomersen
Severity: Moderate
Meclofenamic acid and Mipomersen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mipomersen can cause hepatotoxicity with elevated transaminases, and NSAIDs including meclofenamic acid can occasionally cause liver enzyme elevations. Using both may complicate monitoring and add to hepatic risk.
What this interaction means in plain words
Meclofenamic acid and Mipomersen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hepatotoxic potential from two drugs that can independently raise liver enzymes.
What to do
Monitor liver enzymes at baseline and regularly as required by mipomersen labeling, and stop the NSAID or reassess therapy if transaminases rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Frequently asked questions
Can I take Meclofenamic acid with Mipomersen?
MediHelp rates the interaction as moderate. Meclofenamic acid and Mipomersen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mipomersen can cause hepatotoxicity with elevated transaminases, and NSAIDs including meclofenamic acid can occasionally cause liver enzyme elevations. Using both may complicate monitoring and add to hepatic risk.
How serious is the interaction between Meclofenamic acid and Mipomersen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes at baseline and regularly as required by mipomersen labeling, and stop the NSAID or reassess therapy if transaminases rise.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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