Drug interactions
Meclofenamic acid + Mycophenolate
Severity: Moderate
Meclofenamic acid and Mycophenolate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mycophenolic acid glucuronide is eliminated partly by renal tubular secretion, and NSAIDs may compete for this pathway. Exposure to the metabolite may rise, particularly with renal impairment, and the combination also adds gastrointestinal toxicity risk.
What this interaction means in plain words
Meclofenamic acid and Mycophenolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competition for renal tubular secretion of mycophenolic acid glucuronide, with additive GI mucosal toxicity.
What to do
Monitor renal function, blood counts and GI symptoms. Avoid combination in patients with significant renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Frequently asked questions
Can I take Meclofenamic acid with Mycophenolate?
MediHelp rates the interaction as moderate. Meclofenamic acid and Mycophenolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mycophenolic acid glucuronide is eliminated partly by renal tubular secretion, and NSAIDs may compete for this pathway. Exposure to the metabolite may rise, particularly with renal impairment, and the combination also adds gastrointestinal toxicity risk.
How serious is the interaction between Meclofenamic acid and Mycophenolate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function, blood counts and GI symptoms. Avoid combination in patients with significant renal impairment.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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