Drug interactions
Meclofenamic acid + Nefazodone
Severity: Moderate
Meclofenamic acid and Nefazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone has serotonergic activity that can reduce platelet serotonin uptake, and NSAIDs impair platelet function and damage gastric mucosa. The combination may increase the risk of bleeding, especially upper gastrointestinal bleeding.
What this interaction means in plain words
Meclofenamic acid and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive platelet dysfunction from serotonin reuptake inhibition and NSAID COX-1 inhibition plus mucosal injury.
What to do
Monitor for GI bleeding signs and consider gastroprotection in at-risk patients. Prefer paracetamol when analgesia is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Frequently asked questions
Can I take Meclofenamic acid with Nefazodone?
MediHelp rates the interaction as moderate. Meclofenamic acid and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nefazodone has serotonergic activity that can reduce platelet serotonin uptake, and NSAIDs impair platelet function and damage gastric mucosa. The combination may increase the risk of bleeding, especially upper gastrointestinal bleeding.
How serious is the interaction between Meclofenamic acid and Nefazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for GI bleeding signs and consider gastroprotection in at-risk patients. Prefer paracetamol when analgesia is needed.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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