Drug interactions
Meclofenamic acid + Neomycin po
Severity: Minor
Meclofenamic acid and Neomycin po: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce renal clearance of aminoglycosides, as documented mainly with indomethacin and ibuprofen in preterm neonates. Oral neomycin has very low systemic absorption, so clinically relevant exposure is unlikely except with damaged gut mucosa or renal failure.
What this interaction means in plain words
Meclofenamic acid and Neomycin po have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
NSAID-related reduction in renal prostaglandin-dependent blood flow and glomerular filtration lowers aminoglycoside clearance.
What to do
No action in typical oral use. In renal impairment or inflamed bowel, monitor renal function and signs of ototoxicity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Frequently asked questions
Can I take Meclofenamic acid with Neomycin po?
MediHelp rates the interaction as minor. Meclofenamic acid and Neomycin po have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs can reduce renal clearance of aminoglycosides, as documented mainly with indomethacin and ibuprofen in preterm neonates. Oral neomycin has very low systemic absorption, so clinically relevant exposure is unlikely except with damaged gut mucosa or renal failure.
How serious is the interaction between Meclofenamic acid and Neomycin po?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action in typical oral use. In renal impairment or inflamed bowel, monitor renal function and signs of ototoxicity.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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