Drug interactions
Meclofenamic acid + Penbutolol
Severity: Moderate
Meclofenamic acid and Penbutolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can blunt the antihypertensive effect of beta-blockers, especially with sustained use. Meclofenamate may also impair renal function and cause fluid retention, further reducing blood pressure control.
What this interaction means in plain words
Meclofenamic acid and Penbutolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of vasodilatory prostaglandins causes sodium and water retention and counteracts beta-blocker effects.
What to do
Monitor blood pressure when starting or stopping the NSAID and adjust antihypertensive therapy as needed. Limit the NSAID dose and duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Frequently asked questions
Can I take Meclofenamic acid with Penbutolol?
MediHelp rates the interaction as moderate. Meclofenamic acid and Penbutolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can blunt the antihypertensive effect of beta-blockers, especially with sustained use. Meclofenamate may also impair renal function and cause fluid retention, further reducing blood pressure control.
How serious is the interaction between Meclofenamic acid and Penbutolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when starting or stopping the NSAID and adjust antihypertensive therapy as needed. Limit the NSAID dose and duration.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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