Drug interactions
Meclofenamic acid + Phenindione
Severity: Major
Meclofenamic acid and Phenindione: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenindione is a vitamin K antagonist anticoagulant, and meclofenamate impairs platelet function and can cause GI ulceration. The combination increases the risk of serious bleeding, and protein-binding displacement may add to the effect.
What this interaction means in plain words
Meclofenamic acid and Phenindione can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive hemostatic impairment: vitamin K antagonism plus NSAID platelet inhibition and mucosal injury.
What to do
Avoid the NSAID and use paracetamol if possible; if combined, monitor INR and watch for bleeding, with gastroprotection considered.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Frequently asked questions
Can I take Meclofenamic acid with Phenindione?
MediHelp rates the interaction as major. Meclofenamic acid and Phenindione can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Phenindione is a vitamin K antagonist anticoagulant, and meclofenamate impairs platelet function and can cause GI ulceration. The combination increases the risk of serious bleeding, and protein-binding displacement may add to the effect.
How serious is the interaction between Meclofenamic acid and Phenindione?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the NSAID and use paracetamol if possible; if combined, monitor INR and watch for bleeding, with gastroprotection considered.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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