Drug interactions
Meclofenamic acid + Prazosin
Severity: Minor
Meclofenamic acid and Prazosin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may blunt the blood pressure lowering effect of alpha-blockers like prazosin. The effect is usually modest but can reduce control of hypertension.
What this interaction means in plain words
Meclofenamic acid and Prazosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Meclofenamic acid belongs to Musculoskeletal; Prazosin belongs to Genitourinary.
Why it happens
NSAIDs inhibit vasodilatory prostaglandin synthesis and promote sodium and fluid retention, opposing antihypertensive action.
What to do
Monitor blood pressure when starting or stopping the NSAID and adjust prazosin if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Other interactions of Prazosin
- Alfuzosin + Prazosin Major
- Amifostine + Prazosin Major
- Avanafil + Prazosin Major
- Doxazosin + Prazosin Major
- Dutasteride-tamsulosin + Prazosin Major
- Phenoxybenzamine + Prazosin Major
Frequently asked questions
Can I take Meclofenamic acid with Prazosin?
MediHelp rates the interaction as minor. Meclofenamic acid and Prazosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs may blunt the blood pressure lowering effect of alpha-blockers like prazosin. The effect is usually modest but can reduce control of hypertension.
How serious is the interaction between Meclofenamic acid and Prazosin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when starting or stopping the NSAID and adjust prazosin if needed.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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