Drug interactions
Meclofenamic acid + Propranolol
Severity: Moderate
Meclofenamic acid and Propranolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce the antihypertensive effect of beta-blockers, particularly with sustained use. Blood pressure control may worsen.
What this interaction means in plain words
Meclofenamic acid and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Meclofenamic acid belongs to Musculoskeletal; Propranolol belongs to Cardiovascular.
Why it happens
NSAID inhibition of vasodilatory renal and vascular prostaglandins causes sodium and water retention, opposing the beta-blocker.
What to do
Monitor blood pressure regularly during concurrent use and adjust the antihypertensive regimen if needed. Use the lowest effective NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Albuterol + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
Frequently asked questions
Can I take Meclofenamic acid with Propranolol?
MediHelp rates the interaction as moderate. Meclofenamic acid and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce the antihypertensive effect of beta-blockers, particularly with sustained use. Blood pressure control may worsen.
How serious is the interaction between Meclofenamic acid and Propranolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure regularly during concurrent use and adjust the antihypertensive regimen if needed. Use the lowest effective NSAID dose for the shortest time.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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