Drug interactions
Meclofenamic acid + Quinapril
Severity: Moderate
Meclofenamic acid and Quinapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can weaken the antihypertensive action of ACE inhibitors and can impair renal function when used with them. Risk is higher in the elderly, in dehydrated patients and in those with pre-existing kidney disease, and hyperkalemia may also occur.
What this interaction means in plain words
Meclofenamic acid and Quinapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAIDs inhibit synthesis of vasodilatory renal prostaglandins, reducing renal perfusion and opposing ACE inhibitor effects.
What to do
Monitor blood pressure, serum creatinine and potassium at the start and during combined use, and ensure adequate hydration. Limit NSAID dose and duration, or use paracetamol instead where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Meclofenamic acid and Quinapril, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Frequently asked questions
Can I take Meclofenamic acid with Quinapril?
MediHelp rates the interaction as moderate. Meclofenamic acid and Quinapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can weaken the antihypertensive action of ACE inhibitors and can impair renal function when used with them. Risk is higher in the elderly, in dehydrated patients and in those with pre-existing kidney disease, and hyperkalemia may also occur.
How serious is the interaction between Meclofenamic acid and Quinapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium at the start and during combined use, and ensure adequate hydration. Limit NSAID dose and duration, or use paracetamol instead where possible.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
