Drug interactions
Meclofenamic acid + Reteplase
Severity: Major
Meclofenamic acid and Reteplase: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Reteplase is a thrombolytic, and concurrent drugs that impair platelet function raise the risk of serious hemorrhage. NSAIDs add gastrointestinal and bleeding risk in this setting.
What this interaction means in plain words
Meclofenamic acid and Reteplase can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Thrombolytic fibrinolysis combined with NSAID platelet inhibition produces additive bleeding tendency.
What to do
Avoid starting NSAIDs around thrombolytic therapy and monitor closely for bleeding. Use non-NSAID analgesia where possible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Frequently asked questions
Can I take Meclofenamic acid with Reteplase?
MediHelp rates the interaction as major. Meclofenamic acid and Reteplase can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Reteplase is a thrombolytic, and concurrent drugs that impair platelet function raise the risk of serious hemorrhage. NSAIDs add gastrointestinal and bleeding risk in this setting.
How serious is the interaction between Meclofenamic acid and Reteplase?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid starting NSAIDs around thrombolytic therapy and monitor closely for bleeding. Use non-NSAID analgesia where possible.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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