Drug interactions
Meclofenamic acid + Tenofovir df
Severity: Major
Meclofenamic acid and Tenofovir df: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenofovir is cleared by glomerular filtration and tubular secretion and can injure the proximal tubule, while NSAIDs reduce renal perfusion. Concurrent use, especially at high or repeated NSAID doses, has been linked to acute kidney injury.
What this interaction means in plain words
Meclofenamic acid and Tenofovir df can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive renal injury from NSAID hemodynamic effects and tenofovir tubular toxicity, with shared renal elimination pathways.
What to do
Prefer paracetamol or a non-NSAID alternative; if an NSAID is required, use the lowest dose briefly and monitor creatinine and phosphate.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Frequently asked questions
Can I take Meclofenamic acid with Tenofovir df?
MediHelp rates the interaction as major. Meclofenamic acid and Tenofovir df can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tenofovir is cleared by glomerular filtration and tubular secretion and can injure the proximal tubule, while NSAIDs reduce renal perfusion. Concurrent use, especially at high or repeated NSAID doses, has been linked to acute kidney injury.
How serious is the interaction between Meclofenamic acid and Tenofovir df?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer paracetamol or a non-NSAID alternative; if an NSAID is required, use the lowest dose briefly and monitor creatinine and phosphate.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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