Drug interactions
Meclofenamic acid + Ticarcillin
Severity: Moderate
Meclofenamic acid and Ticarcillin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce renal tubular secretion of penicillins, which may prolong ticarcillin exposure. Meclofenamic acid also impairs platelet function and ticarcillin can cause platelet dysfunction, so bleeding risk may rise in susceptible patients.
What this interaction means in plain words
Meclofenamic acid and Ticarcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competition for renal tubular organic anion secretion, plus additive antiplatelet effects of both drugs.
What to do
Monitor for bleeding and signs of beta-lactam toxicity such as neurotoxicity, especially in renal impairment. Adjust ticarcillin dose to renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Frequently asked questions
Can I take Meclofenamic acid with Ticarcillin?
MediHelp rates the interaction as moderate. Meclofenamic acid and Ticarcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce renal tubular secretion of penicillins, which may prolong ticarcillin exposure. Meclofenamic acid also impairs platelet function and ticarcillin can cause platelet dysfunction, so bleeding risk may rise in susceptible patients.
How serious is the interaction between Meclofenamic acid and Ticarcillin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and signs of beta-lactam toxicity such as neurotoxicity, especially in renal impairment. Adjust ticarcillin dose to renal function.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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