Drug interactions
Meclofenamic acid + Tobramycin inhaled
Severity: Moderate
Meclofenamic acid and Tobramycin inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inhaled tobramycin has low systemic absorption, but some enters the circulation and may accumulate with renal impairment. NSAIDs can reduce renal function and aminoglycoside clearance, which could add to nephrotoxicity or ototoxicity.
What this interaction means in plain words
Meclofenamic acid and Tobramycin inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID-induced reduction in renal perfusion and aminoglycoside clearance, adding to aminoglycoside nephrotoxicity.
What to do
Monitor serum creatinine and, if renal function is reduced, tobramycin levels; use a non-NSAID analgesic where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Frequently asked questions
Can I take Meclofenamic acid with Tobramycin inhaled?
MediHelp rates the interaction as moderate. Meclofenamic acid and Tobramycin inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Inhaled tobramycin has low systemic absorption, but some enters the circulation and may accumulate with renal impairment. NSAIDs can reduce renal function and aminoglycoside clearance, which could add to nephrotoxicity or ototoxicity.
How serious is the interaction between Meclofenamic acid and Tobramycin inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and, if renal function is reduced, tobramycin levels; use a non-NSAID analgesic where possible.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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