Drug interactions
Meclofenamic acid + Venlafaxine
Severity: Moderate
Meclofenamic acid and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Venlafaxine inhibits serotonin uptake into platelets, and with an NSAID the risk of bleeding, especially gastrointestinal, is increased.
What this interaction means in plain words
Meclofenamic acid and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Meclofenamic acid belongs to Musculoskeletal; Venlafaxine belongs to Central Nervous System.
Why it happens
Impaired platelet aggregation from serotonin depletion adds to NSAID COX-1 inhibition and gastric mucosal injury.
What to do
Monitor for GI bleeding and bruising, and consider a proton pump inhibitor in older or high-risk patients. Limit NSAID duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Frequently asked questions
Can I take Meclofenamic acid with Venlafaxine?
MediHelp rates the interaction as moderate. Meclofenamic acid and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Venlafaxine inhibits serotonin uptake into platelets, and with an NSAID the risk of bleeding, especially gastrointestinal, is increased.
How serious is the interaction between Meclofenamic acid and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for GI bleeding and bruising, and consider a proton pump inhibitor in older or high-risk patients. Limit NSAID duration.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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