Drug interactions
Meclofenamic acid + Vorapaxar
Severity: Major
Meclofenamic acid and Vorapaxar: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vorapaxar is a potent antiplatelet agent and meclofenamic acid also impairs platelet aggregation and can irritate the gastric lining. Combined use raises the risk of clinically significant bleeding.
What this interaction means in plain words
Meclofenamic acid and Vorapaxar can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive antiplatelet effect through PAR-1 antagonism and cyclooxygenase inhibition, plus NSAID mucosal injury.
What to do
Avoid regular NSAID use with vorapaxar where possible and monitor for bleeding signs and hemoglobin. Choose acetaminophen for analgesia if suitable.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Frequently asked questions
Can I take Meclofenamic acid with Vorapaxar?
MediHelp rates the interaction as major. Meclofenamic acid and Vorapaxar can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vorapaxar is a potent antiplatelet agent and meclofenamic acid also impairs platelet aggregation and can irritate the gastric lining. Combined use raises the risk of clinically significant bleeding.
How serious is the interaction between Meclofenamic acid and Vorapaxar?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use with vorapaxar where possible and monitor for bleeding signs and hemoglobin. Choose acetaminophen for analgesia if suitable.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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