Drug interactions
Meclofenamic acid + Willow bark
Severity: Moderate
Meclofenamic acid and Willow bark: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Willow bark contains salicin, converted to salicylic acid, so it adds salicylate exposure on top of a nonselective NSAID. This may increase gastrointestinal irritation, bleeding tendency and renal effects, and the two may compete for renal tubular secretion.
What this interaction means in plain words
Meclofenamic acid and Willow bark can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive COX inhibition by salicylate from willow bark and the NSAID, with possible shared renal anion secretion.
What to do
Avoid concurrent use of willow bark with NSAIDs. If it occurs, monitor for gastrointestinal bleeding and renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Frequently asked questions
Can I take Meclofenamic acid with Willow bark?
MediHelp rates the interaction as moderate. Meclofenamic acid and Willow bark can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Willow bark contains salicin, converted to salicylic acid, so it adds salicylate exposure on top of a nonselective NSAID. This may increase gastrointestinal irritation, bleeding tendency and renal effects, and the two may compete for renal tubular secretion.
How serious is the interaction between Meclofenamic acid and Willow bark?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of willow bark with NSAIDs. If it occurs, monitor for gastrointestinal bleeding and renal function.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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