Drug interactions
Meloxicam + Methyclothiazide
Severity: Moderate
Meloxicam and Methyclothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can blunt the antihypertensive and diuretic effects of thiazides by reducing renal prostaglandin synthesis and causing sodium and fluid retention. Together with a thiazide, an NSAID can also raise the risk of acute kidney injury, especially in dehydrated or older patients.
What this interaction means in plain words
Meloxicam and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of renal prostaglandins reduces natriuresis and renal perfusion, antagonising thiazide effects.
What to do
Monitor blood pressure, renal function and electrolytes, and ensure adequate hydration. Use the lowest effective meloxicam dose for the shortest duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Frequently asked questions
Can I take Meloxicam with Methyclothiazide?
MediHelp rates the interaction as moderate. Meloxicam and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can blunt the antihypertensive and diuretic effects of thiazides by reducing renal prostaglandin synthesis and causing sodium and fluid retention. Together with a thiazide, an NSAID can also raise the risk of acute kidney injury, especially in dehydrated or older patients.
How serious is the interaction between Meloxicam and Methyclothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and electrolytes, and ensure adequate hydration. Use the lowest effective meloxicam dose for the shortest duration.
What other medicines interact with Meloxicam?
MediHelp also lists interactions of Meloxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meloxicam page.
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